Due to the threats of habit, abuse, and misuse with opioids, even at encouraged doses [see Warnings and Precautions (5.one)], reserve Promethazine HCl and Codeine Phosphate Oral Alternative for use in Grownup individuals for whom the advantages of cough suppression are envisioned to outweigh the hazards, As well as in whom an adequate assessment of your etiology from the cough has actually been produced.
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In animal replica scientific tests, codeine administered with the oral route to pregnant rats in the duration of organogenesis enhanced resorptions and lessened fetal weights in a dose around 25 situations the maximum recommended human dose (MRHD) during the presence of maternal toxicity (see Information).
Epinephrine - Due to the prospective for promethazine to reverse epinephrine’s vasopressor outcome, epinephrine should NOT be made use of to treat hypotension affiliated with promethazine overdose.
Usually do not acquire promethazine/codeine unless it's been prescribed for you by a healthcare service provider. Just take it as prescribed.
2) Spot the combination in the sealable bag, vacant can, or other container to forestall the drug from leaking or breaking out of a rubbish bag, or to get rid of in more info accordance with regional condition suggestions and/or laws.
與其它鴉片類藥物一樣，可待因的其中一個潛在的嚴重不良反應是壓抑呼吸，通常與服用過量有關，可引致死亡。
Animal replica reports haven't been executed with the drug mixture-promethazine and codeine. It is not regarded no matter whether this drug combination click here could potentially cause fetal harm when administered to the pregnant girl or can impact replica capacity.
Codeine wasn't mutagenic inside the in vitro bacterial reverse mutation assay or clastogenic check here inside the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
Dr Cave additional: “Codeine dependancy can be quite a gradual procedure. If you have been using it for a very long time and wish to stop, you may speak with your Health care provider and decrease the amount of money you take gradually.
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This is much more likely to happen If you don't Possess a gallbladder. Halt taking promethazine/codeine and obtain crisis support In case you have new or even worse abdomen suffering or ache from the upper more info appropriate facet of one's abdomen-space that travels for your back again or shoulder, with or without nausea and vomiting.
Codeine and its salts are very well absorbed following each oral and parenteral administration. Codeine is about 2/3 as powerful orally as parenterally. Codeine is metabolized principally in the liver by enzymes from the endoplasmic reticulum, in which it Actavis promethazine codeine undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
A few other medicines may alter the blood levels of promethazine/codeine, or vice versa. Convey to your healthcare provider about all medicines that you choose or have recently taken.